Dr. Pedram Shojai
Episode Description:
Are you spending hundreds of dollars a month on supplements you can’t even remember why you’re taking? Dr. Pedram Shojai exposes how the $50 billion supplement industry has convinced health-conscious people to swallow 20-30 pills daily—creating more confusion and expense than actual health benefits. He reveals the uncomfortable truth: most people are medicating symptoms they don’t have, optimizing pathways that aren’t broken, and actually creating deficiencies through nutrient competition and over-supplementation.
In this practical discussion, Dr. Shojai provides an evidence-based framework for strategic supplementation, including the three core supplements most people actually need and a decision tree to eliminate unnecessary pills. You’ll learn why “test, don’t guess” is the most important principle, discover which of three supplement user types you are, and understand why the healthiest people aren’t taking the most supplements—they’re taking the right ones for specific needs, for appropriate durations, and they know when to stop. This episode will save you money, reduce your pill burden, and help you focus on what truly moves the needle in your health.
Listen to the episode on Spotify here or on your favorite podcast platform and check out the Urban Monk Academy here.
Podcast show notes:
Key Topics Covered
The Supplement Trap [00:00:00]
- The reality check: counting bottles in your supplement cabinet
- Why people spend $300-500/month on 20-30 pills daily
- The uncomfortable truth: more supplements don’t equal more health
The Industry’s Dirty Secret [00:03:00]
- How the $50 billion supplement industry creates anxiety about deficiencies
- Marketing psychology: universal deficiencies, optimization promises, and biohacker fantasies
- Why you’re medicating symptoms you probably don’t have
Hidden Problems With Over-Supplementation [00:05:00]
- Nutrient competition and interference (calcium blocks iron, zinc competes with copper)
- Creating deficiencies by over-supplementing
- Liver and kidney burden from processing excess nutrients
- The cost of expensive urine from mega-dosing water-soluble vitamins
Three Types of Supplement Users [00:07:00]
- The Deficiency Corrector (appropriate use): Confirmed deficiencies via testing, targeted supplements temporarily, retest and adjust
- The Optimization Chaser (the trap): Already healthy but wanting peak performance, taking everything that might help
- The Symptom Medicator (misguided): Treating symptoms with pills instead of addressing root causes
Evidence-Based Priority Stacking [00:09:00]
Tier One – The Foundation: Test, Don’t Guess
- Vitamin D [00:10:00]: 40% of Americans are deficient; test 25-hydroxy vitamin D; dose 1,000-5,000 IU with K2
- Omega-3s [00:11:00]: Poor omega-3 to -6 ratios in most Americans; Omega-3 index test targeting >8%; dose 1-2g combined EPA/DHA daily
- Magnesium [00:11:00]: RBC magnesium testing (not serum); 300-400mg; glycinate for sleep/calming, threonate for brain, citrate for constipation
- B12 [00:12:00]: Critical for vegetarians/vegans; absorption decreases with age; 500-1,000 micrograms daily of methylcobalamin
Tier Two – Targeted Therapeutics [00:13:00]
- Probiotics: After antibiotics or for confirmed gut dysbiosis only
- Digestive enzymes: Temporary support (30-60 days) while healing the gut, not a lifelong crutch
- Vitamin C: During active infection or immune challenges, days to 1-2 weeks maximum
- Adaptogens: For verified HPA axis dysfunction, 6-12 weeks on, 4 weeks off to avoid suppressing root issues
Tier Three – Usually Unnecessary [00:15:00]
- Most multivitamins are “expensive urine” with subtherapeutic doses
- Kitchen sink formulas with 20+ ingredients provide ineffective dosing
- Exception: Prenatal vitamins during pregnancy
The Decision Tree Framework [00:16:00] Before adding any supplement, ask:
- Do I have a confirmed deficiency or clear symptom? (No = don’t supplement)
- Have I addressed the root cause? (Sleep, stress, diet, movement)
- Is there evidence this supplement addresses my specific issue?
- Can I get this from food or lifestyle changes?
- How will I measure if it’s working?
- What’s my timeline for reassessment?
The Core Three Supplements [00:17:00] For most people, these three cover the most common, impactful deficiencies:
- Vitamin D3 + K2 (morning with fatty meal, monitor every 6 months)
- Omega-3s (1-2g EPA/DHA with meal, monitor index annually)
- Magnesium (evening, 300-400mg, monitor symptom resolution)
The One-at-a-Time Protocol [00:18:00]
- Weeks 1-2: Establish baseline, track symptoms on 1-10 scale
- Weeks 3-6: Add ONE supplement only, track same metrics
- Week 7: Assess improvement or changes
- Weeks 8-12: Retest and evaluate
- Never change multiple things at once or you won’t know what helped
The Paradox of Optimization [00:20:00]
- The healthiest people aren’t taking the most supplements
- Supplements are tools, not a lifestyle—meant to correct deficiencies temporarily
- The more you optimize sleep, stress management, real food, and movement, the less supplementation you need
- Your body is intelligent and often heals without pharmaceutical-grade intervention when given proper foundations
Understanding Practitioner Incentives [00:22:00]
- Acupuncturists get paid for needles, chiropractors for adjustments
- Many naturopaths and functional medicine practitioners generate revenue from supplement sales
- Medical doctors are incentivized to prescribe drugs quickly
- Important to understand these business models when receiving recommendations
Action Steps
- Audit your current supplements using the decision tree
- Eliminate everything you can’t justify with clear reasoning
- Get tested for core nutrients (vitamin D, omega-3 index, magnesium)
- Stop taking anything you can’t identify a clear purpose for
- Check in with yourself in two weeks
Key Takeaways
- Simplicity is the primary medicine
- The goal should be fewer supplements over time, not more
- Supplements should correct deficiencies, support healing temporarily, and bridge gaps—not replace healthy food, sleep, or stress management
- Test, don’t guess
- When you stop managing dozens of bottles and start trusting your body’s wisdom, health becomes simpler, cheaper, and more sustainable
Resources Mentioned
Testing recommendations: 25-hydroxy vitamin D, Omega-3 index, RBC magnesium, serum B12/methylmalonic acid
Third-party tested omega-3 brands: Jeff Bland, Thorne (mentioned as “the gin”)
Various forms of magnesium: glycinate, threonate, citrate
Testing recommendations: 25-hydroxy vitamin D, Omega-3 index, RBC magnesium, serum B12/methylmalonic acid
This episode is for educational purposes only and not intended as medical advice. Consult with qualified healthcare practitioners for personalized guidance.
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