Gut Feeling: How Your Microbiome Affects Your Mood and Mental Health

Have you ever had a “gut feeling” about something? Or felt butterflies in your stomach? It turns out that these sensations are not just metaphors – our gut, or more specifically, our microbiome, can greatly affect both our mood and mental health.

What is the Microbiome?

The microbiome refers to the trillions of microorganisms that live in and on our bodies, particularly in our gut. These microorganisms include bacteria, viruses, fungi, and other microbes. While the idea of having trillions of microorganisms living in our bodies might seem unsettling, the truth is that the microbiome plays a crucial role in our overall health.

Gut-Brain Connection

The gut and the brain are connected through a complex network of nerves, hormones, and biochemical signaling pathways. This connection is known as the gut-brain axis, and it allows the two organs to communicate with each other.

Research has shown that the microbiome can affect the gut-brain axis and thus influence our mood and mental health. For example, some studies have found that people with depression or anxiety have different gut microbiomes than people without these conditions.

The Role of Gut Microbes in Mental Health

Production of Neurotransmitters

Neurotransmitters are chemicals that transmit signals between nerve cells in the brain. Some of the most well-known neurotransmitters include serotonin, dopamine, and norepinephrine.

Interestingly, many of these neurotransmitters are also produced by the gut microbiome. For example, some strains of bacteria in the gut can produce serotonin, which is often referred to as the “happy hormone” because of its effects on mood.


Inflammation is a normal immune response that occurs when the body is trying to fight off infection or injury. However, chronic inflammation has been linked to a number of health problems, including depression and anxiety.

The gut microbiome can affect inflammation levels in the body. For example, some types of bacteria in the gut have been shown to produce anti-inflammatory compounds, while others produce pro-inflammatory compounds.

Immune System Function

The gut microbiome also plays a crucial role in immune system function. This is because a large portion of the immune system is located in the gut.

Research has shown that the microbiome can affect immune system function in a number of ways. For example, some types of bacteria in the gut can stimulate the immune system, while others can suppress it.

How to Support a Healthy Microbiome

Eat a Healthy Diet

A diet that is rich in fiber, fruits, and vegetables can help promote a healthy microbiome. This is because many types of bacteria in the gut thrive on these types of foods. By including a variety of fruits and vegetables with different colors and textures, you can provide a wide range of nutrients that can support the growth of beneficial gut bacteria. Additionally, fiber-rich foods help to feed these bacteria, allowing them to thrive and support overall gut health.

Avoid Antibiotics When Possible

While antibiotics can be life-saving in some situations, they should be used judiciously. Overuse of antibiotics can lead to antibiotic resistance and disrupt the balance of bacteria in the gut, which can have negative effects on our overall health. Therefore, it’s important to avoid unnecessary antibiotic use whenever possible and consult with a healthcare professional before taking antibiotics.

Consider Probiotics

Probiotics are beneficial for your digestive system and overall health as they contain live bacteria and yeasts. While more research is necessary, studies have indicated that taking probiotics may help support a healthy microbiome. Incorporating probiotics into your diet may enhance your gut feeling and promote overall wellness.


While the idea of having trillions of microorganisms living in our bodies might seem strange, the truth is that the microbiome plays a crucial role in our overall health. Research has shown that the microbiome can affect our mood and mental health, and that supporting a healthy microbiome is an important part of overall wellness. By eating a healthy diet, avoiding unnecessary antibiotics, and considering probiotics, we can help support a healthy microbiome and improve our gut feeling.

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Dr. Pedram Shojai

NY Times Best Selling author and film maker. Taoist Abbot and Qigong master. Husband and dad. I’m here to help you find your way and be healthy and happy. I don’t want to be your guru…just someone who’ll help point the way. If you’re looking for a real person who’s done the work, I’m your guy. I can light the path and walk along it with you but can’t walk for you.